Letromina - 2.5MG - 30T
Letrozole’s effects on serum Estrogen level control are perhaps the strongest and most effective of the three major aromatase inhibitors as noted in studies. Even the informational pamphlets included with the pharmaceutical product have stated that at its standard tablet dose of 2.5mg is effective enough to reduce circulating Estrogen levels by an average of 78%. However, actual real clinical data has demonstrated far more effective reductions (remember that 78% is a determined average). Letrozole in studies has exhibited at least 98% reduction or more of serum Estrogen levels. Letrozole can be so effective at inhibiting the aromatase enzyme and thereby reducing Estrogen levels that this compound is typically only administered to post-menopausal females, and/or utilized when other first-line treatments for breast cancer has failed. This is actually a common usage aspect of all three major aromatase inhibitors, as they are all very effective compounds for the purpose of Estrogen reduction, with Letrozole by far being the most effective.
Arimidex and Letrozole are both classified as non-steroidal and non-suicidal aromatase inhibitors that compete with the substrate for binding to the enzyme active site. This is very different from Aromasin (Exemestane), which is a steroidal and suicidal aromatase inhibitor that acts as a mechanism-based steroidal inhibitor that mimics the substrate, is converted by the enzyme to a reactive intermediate, and results in the inactivation of the aromatase enzyme. For ease of understanding, what this means to the layman is that Aromasin’s chemical structure resembles the traditional ‘targets’ that aromatase binds to (Testosterone, for example) and that it essentially ‘fools’ the aromatase enzyme into binding with it, only to become inhibited/deactivated. Because the binding strength is so great, this inhibition becomes permanent for the aromatase enzyme that Aromasin has become bound to. Arimidex and Letrozole, being non-suicidal aromatase inhibitors, both compete with the enzyme’s traditional ‘targets’ rather than being assured a permanent spot (which is the advantage that Aromasin has over the other two).
Letrozole, as is common with all aromatase inhibitors has also demonstrated the ability to increase the endogenous production of LH (Luteinizing Hormone), FSH (Follicle Stimulating Hormone), and consequently, Testosterone levels in men, but this will be further covered in greater detail under the Letrozole doses section of the profile.
Bodybuilders and athletes utilizing anabolic steroids will usually favor aromatase inhibitors such as Letrozole for its ability to eliminate risingEstrogen levels at its root cause: aromatase. By disabling the aromatase enzyme, supraphysiological levels of aromatizable androgens (such as Testosterone, Dianabol, Deca-Durabolin, etc.) cannot convert into Estrogen, thereby eliminating any possible risk of Estrogen-related side effects.